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==Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)-4-methoxybenzenesulfonamide==
==Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)-4-methoxybenzenesulfonamide==
<StructureSection load='4jmo' size='340' side='right' caption='[[4jmo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4jmo' size='340' side='right'caption='[[4jmo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jmo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JMO FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jmo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JMO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JAF:N-(4-HYDROXY-2,6-DIMETHYLPHENYL)-4-METHOXYBENZENESULFONAMIDE'>JAF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jmi|4jmi]], [[4jwl|4jwl]], [[4jxh|4jxh]], [[4l5m|4l5m]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JAF:N-(4-HYDROXY-2,6-DIMETHYLPHENYL)-4-METHOXYBENZENESULFONAMIDE'>JAF</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYTH2, ARNO, PSCD2, PSCD2L ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmo OCA], [https://pdbe.org/4jmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jmo RCSB], [https://www.ebi.ac.uk/pdbsum/4jmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmo OCA], [http://pdbe.org/4jmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jmo RCSB], [http://www.ebi.ac.uk/pdbsum/4jmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CYH2_HUMAN CYH2_HUMAN]] Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.<ref>PMID:17398095</ref>
[https://www.uniprot.org/uniprot/CYH2_HUMAN CYH2_HUMAN] Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane.<ref>PMID:17398095</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hoh, F]]
[[Category: Large Structures]]
[[Category: Rouhana, J]]
[[Category: Hoh F]]
[[Category: Arf1]]
[[Category: Rouhana J]]
[[Category: Nucleotide exchange factor]]
[[Category: Signaling protein-inhibitor complex]]
Retrieved from "https://proteopedia.org/4jmo"