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==Crystal structure of S. cerevisiae Sir3 C-terminal domain==
==Crystal structure of S. cerevisiae Sir3 C-terminal domain==
<StructureSection load='3zco' size='340' side='right' caption='[[3zco]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3zco' size='340' side='right'caption='[[3zco]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3zco]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZCO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3zco]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZCO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zco OCA], [http://pdbe.org/3zco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zco RCSB], [http://www.ebi.ac.uk/pdbsum/3zco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zco ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zco OCA], [https://pdbe.org/3zco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zco RCSB], [https://www.ebi.ac.uk/pdbsum/3zco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zco ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.  
[https://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Gasser, S M]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Gut, H]]
[[Category: Gasser SM]]
[[Category: Hassler, M]]
[[Category: Gut H]]
[[Category: Keusch, J J]]
[[Category: Hassler M]]
[[Category: Kueng, S]]
[[Category: Keusch JJ]]
[[Category: Ladurner, A G]]
[[Category: Kueng S]]
[[Category: Oppikofer, M]]
[[Category: Ladurner AG]]
[[Category: Dimerization]]
[[Category: Oppikofer M]]
[[Category: Transcription]]
[[Category: Winged-helix like domain]]