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==EthR from Mycobacterium tuberculosis in complex with compound BDM31379==
==EthR from Mycobacterium tuberculosis in complex with compound BDM31379==
<StructureSection load='3q0u' size='340' side='right' caption='[[3q0u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3q0u' size='340' side='right'caption='[[3q0u]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3q0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q0U FirstGlance]. <br>
<table><tr><td colspan='2'>[[3q0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q0U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LL3:2-PHENYL-1-{4-[3-(THIOPHEN-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}ETHANONE'>LL3</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o8g|3o8g]], [[3o8l|3o8l]], [[3g1m|3g1m]], [[3g1l|3g1l]], [[3g1o|3g1o]], [[1u9n|1u9n]], [[3q0v|3q0v]], [[3q0w|3q0w]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LL3:2-PHENYL-1-{4-[3-(THIOPHEN-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}ETHANONE'>LL3</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ethR, etaR, MT3970, Rv3855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0u OCA], [https://pdbe.org/3q0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q0u RCSB], [https://www.ebi.ac.uk/pdbsum/3q0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q0u OCA], [http://pdbe.org/3q0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3q0u RCSB], [http://www.ebi.ac.uk/pdbsum/3q0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3q0u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>  
 
==See Also==
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baulard, A]]
[[Category: Large Structures]]
[[Category: Brodin, P]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Carette, X]]
[[Category: Baulard A]]
[[Category: Christophe, T]]
[[Category: Brodin P]]
[[Category: Demirkaya, F]]
[[Category: Carette X]]
[[Category: Deprez, B]]
[[Category: Christophe T]]
[[Category: Desroses, M]]
[[Category: Demirkaya F]]
[[Category: Dirie, B]]
[[Category: Deprez B]]
[[Category: Flipo, M]]
[[Category: Desroses M]]
[[Category: Jeon, H K]]
[[Category: Dirie B]]
[[Category: Lens, Z]]
[[Category: Flipo M]]
[[Category: Leroux, F]]
[[Category: Jeon HK]]
[[Category: Locht, C]]
[[Category: Lens Z]]
[[Category: Piveteau, C]]
[[Category: Leroux F]]
[[Category: Rucktooa, P]]
[[Category: Locht C]]
[[Category: Villeret, V]]
[[Category: Piveteau C]]
[[Category: Willand, N]]
[[Category: Rucktooa P]]
[[Category: Tetr family]]
[[Category: Villeret V]]
[[Category: Transcription-transcription inhibitor complex]]
[[Category: Willand N]]
[[Category: Transcriptional repressor]]

Latest revision as of 10:45, 21 February 2024

EthR from Mycobacterium tuberculosis in complex with compound BDM31379

3q0u, resolution 1.70Å

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