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[[Image:1km8.jpg|left|200px]]


{{Structure
==The Structure of a Cytotoxic Ribonuclease From the Oocyte of Rana Catesbeiana (Bullfrog)==
|PDB= 1km8 |SIZE=350|CAPTION= <scene name='initialview01'>1km8</scene>, resolution 1.90&Aring;
<StructureSection load='1km8' size='340' side='right'caption='[[1km8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE=
== Structural highlights ==
|LIGAND= <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
<table><tr><td colspan='2'>[[1km8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_catesbeianus Lithobates catesbeianus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KM8 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1km8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1km8 OCA], [https://pdbe.org/1km8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1km8 RCSB], [https://www.ebi.ac.uk/pdbsum/1km8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1km8 ProSAT]</span></td></tr>
|RELATEDENTRY=[[1bc4|1BC4]], [[1km9|1KM9]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1km8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1km8 OCA], [http://www.ebi.ac.uk/pdbsum/1km8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1km8 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/RNASO_AQUCT RNASO_AQUCT] Preferentially cleaves single-stranded RNA at pyrimidine residues with a 3'flanking guanine. Hydrolyzes poly(U) and poly(C) as substrates, and prefers the former. The S-lectins in frog eggs may be involved in the fertilization and development of the frog embryo. This lectin agglutinates various animal cells, including normal lymphocytes, erythrocytes, and fibroblasts of animal and human origin. It is cytotoxic against several tumor cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/1km8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1km8 ConSurf].
<div style="clear:both"></div>


'''The Structure of a Cytotoxic Ribonuclease From the Oocyte of Rana Catesbeiana (Bullfrog)'''
==See Also==
 
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1KM8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rana_catesbeiana Rana catesbeiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KM8 OCA].
[[Category: Large Structures]]
[[Category: Pancreatic ribonuclease]]
[[Category: Lithobates catesbeianus]]
[[Category: Rana catesbeiana]]
[[Category: Amiraslanov IR]]
[[Category: Single protein]]
[[Category: Chern S-S]]
[[Category: Amiraslanov, I R.]]
[[Category: Liao Y-D]]
[[Category: Chern, S S.]]
[[Category: Liaw Y-C]]
[[Category: Liao, Y D.]]
[[Category: Musayev FN]]
[[Category: Liaw, Y C.]]
[[Category: Musayev, F N.]]
[[Category: rc-rnase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:50:30 2008''
Retrieved from "https://proteopedia.org/1km8"