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==Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a==
==Crystal structure of the complex between cnto888 fab and mcp-1 mutant p8a==
<StructureSection load='4dn4' size='340' side='right' caption='[[4dn4]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='4dn4' size='340' side='right'caption='[[4dn4]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4dn4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DN4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DN4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4dn4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DN4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DN4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dn3|4dn3]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CCL2, MCP1, SCYA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dn4 OCA], [https://pdbe.org/4dn4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dn4 RCSB], [https://www.ebi.ac.uk/pdbsum/4dn4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dn4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dn4 OCA], [http://pdbe.org/4dn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dn4 RCSB], [http://www.ebi.ac.uk/pdbsum/4dn4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dn4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.  
[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
*[[User:Coline Perrin/CCL2|User:Coline Perrin/CCL2]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Gilliland, G]]
[[Category: Large Structures]]
[[Category: Grygiel, T]]
[[Category: Gilliland G]]
[[Category: L., Snyder]]
[[Category: Grygiel T]]
[[Category: Malia, T]]
[[Category: Malia T]]
[[Category: Obmolova, G]]
[[Category: Obmolova G]]
[[Category: Sweet, R]]
[[Category: Snyder L]]
[[Category: Teplyakov, A]]
[[Category: Sweet R]]
[[Category: Antibody chemokine]]
[[Category: Teplyakov A]]
[[Category: Immune system]]
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