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==X-RAY STRUCTURE OF THE SUBSTRATE-FREE CYTOCHROME P450 PIMD -A POLYENE MACROLIDE ANTIBIOTIC PIMARICIN EPOXIDASE==
==X-ray structure of the substrate-free cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase==
<StructureSection load='2x9p' size='340' side='right' caption='[[2x9p]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2x9p' size='340' side='right'caption='[[2x9p]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_natalensis"_struyk_et_al._1958 "streptomyces natalensis" struyk et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X9P FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x9p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_natalensis Streptomyces natalensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X9P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xbk|2xbk]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9p OCA], [http://pdbe.org/2x9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x9p RCSB], [http://www.ebi.ac.uk/pdbsum/2x9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9p OCA], [https://pdbe.org/2x9p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x9p RCSB], [https://www.ebi.ac.uk/pdbsum/2x9p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9EW92_9ACTN Q9EW92_9ACTN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/2x9p_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/2x9p_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Streptomyces natalensis struyk et al. 1958]]
[[Category: Large Structures]]
[[Category: Aparicio, J F]]
[[Category: Streptomyces natalensis]]
[[Category: Kells, P M]]
[[Category: Aparicio JF]]
[[Category: Ouellet, H]]
[[Category: Kells PM]]
[[Category: Podust, L M]]
[[Category: Ouellet H]]
[[Category: Santos-Aberturas, J]]
[[Category: Podust LM]]
[[Category: Epoxidation]]
[[Category: Santos-Aberturas J]]
[[Category: Oxidoreductase]]

Latest revision as of 17:40, 8 September 2026

X-ray structure of the substrate-free cytochrome P450 PimD - a polyene macrolide antibiotic pimaricin epoxidase

2x9p, resolution 2.10Å

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