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==LpxC from A.Aaeolicus in complex with 4-[[4-[2-[4-(morpholinomethyl)phenyl]ethynyl]phenoxy]methyl]tetrahydropyran-4-carbohydroxamic acid (compound 9)==
==LpxC from A.Aaeolicus in complex with 4-[[4-[2-[4-(morpholinomethyl)phenyl]ethynyl]phenoxy]methyl]tetrahydropyran-4-carbohydroxamic acid (compound 9)==
<StructureSection load='4u3d' size='340' side='right' caption='[[4u3d]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
<StructureSection load='4u3d' size='340' side='right'caption='[[4u3d]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4u3d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U3D FirstGlance]. <br>
<table><tr><td colspan='2'>[[4u3d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus_VF5 Aquifex aeolicus VF5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U3D FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3BX:N-HYDROXY-4-[(4-{[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ETHYNYL}PHENOXY)METHYL]TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE'>3BX</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u3d OCA], [http://pdbe.org/4u3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u3d RCSB], [http://www.ebi.ac.uk/pdbsum/4u3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u3d ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3BX:N-HYDROXY-4-[(4-{[4-(MORPHOLIN-4-YLMETHYL)PHENYL]ETHYNYL}PHENOXY)METHYL]TETRAHYDRO-2H-PYRAN-4-CARBOXAMIDE'>3BX</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u3d OCA], [https://pdbe.org/4u3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u3d RCSB], [https://www.ebi.ac.uk/pdbsum/4u3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u3d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).  
[https://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4u3d" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4u3d" style="background-color:#fffaf0;"></div>
==See Also==
*[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Olivier, N B]]
[[Category: Aquifex aeolicus VF5]]
[[Category: Antibacterial]]
[[Category: Large Structures]]
[[Category: Gram negative bacteria]]
[[Category: Olivier NB]]
[[Category: Hydrolase]]
[[Category: Hydrophobe]]
[[Category: Lpxc]]
[[Category: Mmp]]
Retrieved from "https://proteopedia.org/4u3d"