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==Crystal Structure Analysis of M32A mutant of human CLIC1==
==Crystal Structure Analysis of M32A mutant of human CLIC1==
<StructureSection load='3o3t' size='340' side='right' caption='[[3o3t]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3o3t' size='340' side='right'caption='[[3o3t]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o3t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ma4 3ma4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O3T FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o3t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ma4 3ma4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O3T FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLIC1, G6, NCC27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3t OCA], [http://pdbe.org/3o3t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o3t RCSB], [http://www.ebi.ac.uk/pdbsum/3o3t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o3t ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3t OCA], [https://pdbe.org/3o3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o3t RCSB], [https://www.ebi.ac.uk/pdbsum/3o3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o3t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/3o3t_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o3/3o3t_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Ion channels|Ion channels]]
*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Achilonu, I A]]
[[Category: Large Structures]]
[[Category: Adamson, R J]]
[[Category: Achilonu IA]]
[[Category: Dirr, H W]]
[[Category: Adamson RJ]]
[[Category: Fanucchi, S]]
[[Category: Dirr HW]]
[[Category: Fernandes, M A]]
[[Category: Fanucchi S]]
[[Category: Stoychev, S]]
[[Category: Fernandes MA]]
[[Category: Clic]]
[[Category: Stoychev S]]
[[Category: Domain interface]]
[[Category: Glutathione transferase]]
[[Category: Ion channel]]
[[Category: Thioredoxin]]
[[Category: Transport protein]]

Latest revision as of 10:32, 21 February 2024

Crystal Structure Analysis of M32A mutant of human CLIC1

3o3t, resolution 1.70Å

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