4f11: Difference between revisions

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==Crystal structure of the extracellular domain of human GABA(B) receptor GBR2==
==Crystal structure of the extracellular domain of human GABA(B) receptor GBR2==
<StructureSection load='4f11' size='340' side='right' caption='[[4f11]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
<StructureSection load='4f11' size='340' side='right'caption='[[4f11]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4f11]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F11 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4f11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F11 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABBR2, GPR51, GPRC3B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f11 OCA], [http://pdbe.org/4f11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f11 RCSB], [http://www.ebi.ac.uk/pdbsum/4f11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f11 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f11 OCA], [https://pdbe.org/4f11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f11 RCSB], [https://www.ebi.ac.uk/pdbsum/4f11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f11 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/GABR2_HUMAN GABR2_HUMAN]] Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.<ref>PMID:9872316</ref> <ref>PMID:10328880</ref> <ref>PMID:18165688</ref> <ref>PMID:22660477</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[GABA receptor|GABA receptor]]
*[[GABA receptor 3D structures|GABA receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Burmakina, S]]
[[Category: Large Structures]]
[[Category: Bush, M]]
[[Category: Burmakina S]]
[[Category: Chen, Y]]
[[Category: Bush M]]
[[Category: Fan, Q R]]
[[Category: Chen Y]]
[[Category: Geng, Y]]
[[Category: Fan QR]]
[[Category: Javitch, J A]]
[[Category: Geng Y]]
[[Category: Kniazeff, J]]
[[Category: Javitch JA]]
[[Category: Malito, D L]]
[[Category: Kniazeff J]]
[[Category: Mosyak, L]]
[[Category: Malito DL]]
[[Category: Pin, J P]]
[[Category: Mosyak L]]
[[Category: Quick, M]]
[[Category: Pin J-P]]
[[Category: Xiong, D]]
[[Category: Quick M]]
[[Category: G-protein coupled receptor]]
[[Category: Xiong D]]
[[Category: Signaling protein]]
[[Category: Venus flytrap module]]
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