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==Crystal structure of AcrB-AcrZ complex==
==Crystal structure of AcrB-AcrZ complex==
<StructureSection load='4c48' size='340' side='right' caption='[[4c48]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<StructureSection load='4c48' size='340' side='right'caption='[[4c48]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c48]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli], [http://en.wikipedia.org/wiki/Ecow3 Ecow3] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C48 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C48 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c48]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12], [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._W3110 Escherichia coli str. K-12 substr. W3110] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C48 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c48 OCA], [http://pdbe.org/4c48 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c48 RCSB], [http://www.ebi.ac.uk/pdbsum/4c48 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c48 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c48 OCA], [https://pdbe.org/4c48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c48 RCSB], [https://www.ebi.ac.uk/pdbsum/4c48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c48 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI]] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref> [[http://www.uniprot.org/uniprot/ACRZ_ECOLI ACRZ_ECOLI]] AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.<ref>PMID:23010927</ref> 
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Ecow3]]
[[Category: Escherichia coli str. K-12 substr. W3110]]
[[Category: Synthetic construct sequences]]
[[Category: Large Structures]]
[[Category: Du, D]]
[[Category: Synthetic construct]]
[[Category: James, N]]
[[Category: Du D]]
[[Category: Klimont, E]]
[[Category: James N]]
[[Category: Luisi, B F]]
[[Category: Klimont E]]
[[Category: Drug efflux]]
[[Category: Luisi BF]]
[[Category: Transmembrane protein]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4c48"