3t5c: Difference between revisions

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==Crystal structure of N-terminal domain of FACL13 from Mycobacterium tuberculosis in different space group C2==
==Crystal structure of N-terminal domain of FACL13 from Mycobacterium tuberculosis in different space group C2==
<StructureSection load='3t5c' size='340' side='right' caption='[[3t5c]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
<StructureSection load='3t5c' size='340' side='right'caption='[[3t5c]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3t5c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T5C FirstGlance]. <br>
<table><tr><td colspan='2'>[[3t5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T5C FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t5a|3t5a]], [[3t5b|3t5b]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fadD13, MT3174, Rv3089 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5c OCA], [https://pdbe.org/3t5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t5c RCSB], [https://www.ebi.ac.uk/pdbsum/3t5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t5c OCA], [http://pdbe.org/3t5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3t5c RCSB], [http://www.ebi.ac.uk/pdbsum/3t5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3t5c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FAC13_MYCTU FAC13_MYCTU]] Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16).<ref>PMID:15937179</ref> <ref>PMID:20027301</ref> <ref>PMID:22560731</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Myctu]]
[[Category: Large Structures]]
[[Category: Goyal, A]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Sankaranarayanan, R]]
[[Category: Goyal A]]
[[Category: Acetyl-coa synthetase like fold]]
[[Category: Sankaranarayanan R]]
[[Category: Amp-binding]]
[[Category: Ligase]]
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