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==Crystal structure of 3-ketosteroid-9-alpha-hydroxylase (KshA) from M. tuberculosis in complex with 4-androstene-3,17-dione==
==Crystal structure of 3-ketosteroid-9-alpha-hydroxylase (KshA) from M. tuberculosis in complex with 4-androstene-3,17-dione==
<StructureSection load='4qck' size='340' side='right' caption='[[4qck]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
<StructureSection load='4qck' size='340' side='right'caption='[[4qck]], [[Resolution|resolution]] 2.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qck]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QCK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QCK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qck]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QCK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASD:4-ANDROSTENE-3-17-DIONE'>ASD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qdc|4qdc]], [[4qdd|4qdd]], [[4qdf|4qdf]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASD:4-ANDROSTENE-3-17-DIONE'>ASD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-ketosteroid_9-alpha-monooxygenase 3-ketosteroid 9-alpha-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.142 1.14.13.142] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qck OCA], [https://pdbe.org/4qck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qck RCSB], [https://www.ebi.ac.uk/pdbsum/4qck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qck ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qck OCA], [http://pdbe.org/4qck PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qck RCSB], [http://www.ebi.ac.uk/pdbsum/4qck PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qck ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KSHA_MYCTU KSHA_MYCTU]] Catalyzes the opening of ring B of 1,4-androstadiene-3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta-cleavage.  
[https://www.uniprot.org/uniprot/KSHA_MYCTU KSHA_MYCTU] Catalyzes the opening of ring B of 1,4-androstadiene-3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta-cleavage.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3-ketosteroid 9-alpha-monooxygenase]]
[[Category: Large Structures]]
[[Category: Eltis, L D]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Penfield, J]]
[[Category: Eltis LD]]
[[Category: Strynadka, N C]]
[[Category: Penfield J]]
[[Category: Worrall, L J]]
[[Category: Strynadka NC]]
[[Category: Mixed function oxygenase]]
[[Category: Worrall LJ]]
[[Category: Oxidoreductase]]
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