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==DNA polymerase beta with a gapped DNA substrate and dTMP(CF2)P(CF2)P==
==DNA polymerase beta with a gapped DNA substrate and dTMP(CF2)P(CF2)P==
<StructureSection load='3lk9' size='340' side='right' caption='[[3lk9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3lk9' size='340' side='right'caption='[[3lk9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3lk9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LK9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3lk9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LK9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TFF:5-O-[(R)-{[(R)-[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL](DIFLUORO)METHYL}(HYDROXY)PHOSPHORYL]THYMIDINE'>TFF</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gdx|3gdx]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TFF:5-O-[(R)-{[(R)-[DIFLUORO(PHOSPHONO)METHYL](HYDROXY)PHOSPHORYL](DIFLUORO)METHYL}(HYDROXY)PHOSPHORYL]THYMIDINE'>TFF</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">POLB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lk9 OCA], [https://pdbe.org/3lk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lk9 RCSB], [https://www.ebi.ac.uk/pdbsum/3lk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lk9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lk9 OCA], [http://pdbe.org/3lk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3lk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lk9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>
[https://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Batra, V K]]
[[Category: Large Structures]]
[[Category: Beard, W A]]
[[Category: Batra VK]]
[[Category: Goodman, M F]]
[[Category: Beard WA]]
[[Category: Kashemirov, B A]]
[[Category: Goodman MF]]
[[Category: McKenna, C E]]
[[Category: Kashemirov BA]]
[[Category: Oertell, K]]
[[Category: McKenna CE]]
[[Category: Pedersen, L C]]
[[Category: Oertell K]]
[[Category: Prakash, G K.Surya]]
[[Category: Pedersen LC]]
[[Category: Upton, T G]]
[[Category: Surya Prakash GK]]
[[Category: Wilson, S H]]
[[Category: Upton TG]]
[[Category: Zibinsky, M]]
[[Category: Wilson SH]]
[[Category: Dna damage]]
[[Category: Zibinsky M]]
[[Category: Dna polyemrase]]
[[Category: Dna repair]]
[[Category: Dna replication]]
[[Category: Dna synthesis]]
[[Category: Dna-binding]]
[[Category: Dna-directed dna polymerase]]
[[Category: Lyase]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Methylation]]
[[Category: Nucleotidyl transferase]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleus]]
[[Category: Transferase]]
[[Category: Transferase-dna complex]]
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