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==Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum==
==Probing the active center of catalase-phenol oxidase from Scytalidium thermophilum==
<StructureSection load='4b7a' size='340' side='right' caption='[[4b7a]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4b7a' size='340' side='right'caption='[[4b7a]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4b7a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycothermus_thermophilus Mycothermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B7A FirstGlance]. <br>
<table><tr><td colspan='2'>[[4b7a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycothermus_thermophilus Mycothermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B7A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3TR:3-AMINO-1,2,4-TRIAZOLE'>3TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HDD:CIS-HEME+D+HYDROXYCHLORIN+GAMMA-SPIROLACTONE'>HDD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4aue|4aue]], [[4aul|4aul]], [[4aum|4aum]], [[4aun|4aun]], [[4b2y|4b2y]], [[4b31|4b31]], [[4b40|4b40]], [[4b5k|4b5k]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3TR:3-AMINO-1,2,4-TRIAZOLE'>3TR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HDD:CIS-HEME+D+HYDROXYCHLORIN+GAMMA-SPIROLACTONE'>HDD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catalase Catalase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7a OCA], [https://pdbe.org/4b7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b7a RCSB], [https://www.ebi.ac.uk/pdbsum/4b7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b7a OCA], [http://pdbe.org/4b7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b7a RCSB], [http://www.ebi.ac.uk/pdbsum/4b7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b7a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/M4GGR5_HUMIN M4GGR5_HUMIN] Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.[RuleBase:RU004142]  Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.[ARBA:ARBA00003918][PIRNR:PIRNR038927]


==See Also==
==See Also==
*[[Catalase|Catalase]]
*[[Catalase 3D structures|Catalase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Catalase]]
[[Category: Large Structures]]
[[Category: Mycothermus thermophilus]]
[[Category: Mycothermus thermophilus]]
[[Category: McPherson, M J]]
[[Category: McPherson MJ]]
[[Category: Ogel, Z B]]
[[Category: Ogel ZB]]
[[Category: Pearson, A R]]
[[Category: Pearson AR]]
[[Category: Trinh, C H]]
[[Category: Trinh CH]]
[[Category: Yuzugullu, Y]]
[[Category: Yuzugullu Y]]
[[Category: Heme catalase]]
[[Category: Molecular channel]]
[[Category: Oxidative activity]]
[[Category: Oxidoreductase]]