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==Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with phenylpyruvic acid==
==Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with phenylpyruvic acid==
<StructureSection load='4kif' size='340' side='right' caption='[[4kif]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4kif' size='340' side='right'caption='[[4kif]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kif]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KIF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kif]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_hygroscopicus Streptomyces hygroscopicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KIF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=PPY:3-PHENYLPYRUVIC+ACID'>PPY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kib|4kib]], [[4kic|4kic]], [[4kig|4kig]], [[4m6x|4m6x]], [[4m6y|4m6y]], [[4m71|4m71]], [[4m72|4m72]], [[4m73|4m73]], [[4m74|4m74]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HF2:(2R)-2-HYDROXY-3-PHENYLPROPANOIC+ACID'>HF2</scene>, <scene name='pdbligand=PPY:3-PHENYLPYRUVIC+ACID'>PPY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kif OCA], [http://pdbe.org/4kif PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kif RCSB], [http://www.ebi.ac.uk/pdbsum/4kif PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kif ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kif OCA], [https://pdbe.org/4kif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kif RCSB], [https://www.ebi.ac.uk/pdbsum/4kif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kif ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MPPJ_STRHY MPPJ_STRHY]] S-adenosyl-L-methionine-dependent methyltransferase involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.  
[https://www.uniprot.org/uniprot/MPPJ_STRHY MPPJ_STRHY] S-adenosyl-L-methionine-dependent methyltransferase involved in synthesis of the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4kif" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4kif" style="background-color:#fffaf0;"></div>
==See Also==
*[[SAM-dependent methyltrasferase 3D structures|SAM-dependent methyltrasferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chan, H C]]
[[Category: Large Structures]]
[[Category: Huang, C J]]
[[Category: Streptomyces hygroscopicus]]
[[Category: Li, T L]]
[[Category: Chan HC]]
[[Category: Liu, Y C]]
[[Category: Huang CJ]]
[[Category: Zou, X W]]
[[Category: Li TL]]
[[Category: Methyltransferase]]
[[Category: Liu YC]]
[[Category: Rossmann fold]]
[[Category: Zou XW]]
[[Category: Sam binding ppy binding]]
[[Category: Transferase]]
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