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==The crystal structure of adenosine deaminase with hypoxanthine bound from Pseudomonas aeruginosa==
==The crystal structure of adenosine deaminase with hypoxanthine bound from Pseudomonas aeruginosa==
<StructureSection load='3pan' size='340' side='right' caption='[[3pan]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
<StructureSection load='3pan' size='340' side='right'caption='[[3pan]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3pan]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PAN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PAN FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PAN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.627&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ou8|3ou8]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pan OCA], [https://pdbe.org/3pan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pan RCSB], [https://www.ebi.ac.uk/pdbsum/3pan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pan ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">add, ADD_PSEAE, PA0148 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosine_deaminase Adenosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.4 3.5.4.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pan OCA], [http://pdbe.org/3pan PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pan RCSB], [http://www.ebi.ac.uk/pdbsum/3pan PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pan ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ADE_PSEAE ADE_PSEAE]] Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity).


==See Also==
==See Also==
*[[Adenosine deaminase|Adenosine deaminase]]
*[[Adenosine deaminase 3D structures|Adenosine deaminase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Adenosine deaminase]]
[[Category: Large Structures]]
[[Category: Burley, S K]]
[[Category: Burley SK]]
[[Category: Structural genomic]]
[[Category: Swaminathan S]]
[[Category: Swaminathan, S]]
[[Category: Zhang Z]]
[[Category: Zhang, Z]]
[[Category: Hydrolase]]
[[Category: Hypoxanthine]]
[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics]]
[[Category: PSI, Protein structure initiative]]
[[Category: Sgx]]

Latest revision as of 06:04, 17 October 2024

The crystal structure of adenosine deaminase with hypoxanthine bound from Pseudomonas aeruginosa

3pan, resolution 2.63Å

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