4bsc: Difference between revisions

<StructureSection load='4bsc' size='340' side='right' caption='[[4bsc]], [[Resolution|resolution]] 2.55&Aring;' scene=''>

<table><tr><td colspan='2'>[[4bsc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9infa 9infa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BSC FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bsa|4bsa]], [[4bsb|4bsb]], [[4bsd|4bsd]], [[4bse|4bse]], [[4bsf|4bsf]], [[4bsg|4bsg]], [[4bsh|4bsh]], [[4bsi|4bsi]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bsc OCA], [http://pdbe.org/4bsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bsc RCSB], [http://www.ebi.ac.uk/pdbsum/4bsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bsc ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/M4YV75_9INFA M4YV75_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]  Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[SAAS:SAAS00204388]  

*[[Hemagglutinin|Hemagglutinin]]

[[Category: Bennett, M S]]

[[Category: Collins, P J]]

[[Category: Daniels, R S]]

[[Category: Gamblin, S J]]

[[Category: Haire, L F]]

[[Category: Martin, S R]]

[[Category: McCauley, J W]]

[[Category: Skehel, J J]]

[[Category: Walker, P A]]

[[Category: Wharton, S A]]

[[Category: Xiong, X]]

[[Category: Fowl plague virus]]

[[Category: Sialyllactosamine]]

[[Category: Viral protein]]