4ux6: Difference between revisions
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==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)== | ==The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)== | ||
<StructureSection load='4ux6' size='340' side='right' caption='[[4ux6]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='4ux6' size='340' side='right'caption='[[4ux6]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4ux6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UX6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=YWO:O-(5-METHYL-2-NITROPHENYL)-D-TYROSINAMIDE'>YWO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ux6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux6 OCA], [https://pdbe.org/4ux6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ux6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ux6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ux6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4ux6" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4ux6" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Andrews | [[Category: Large Structures]] | ||
[[Category: Beaton | [[Category: Mus musculus]] | ||
[[Category: Birkinshaw | [[Category: Andrews G]] | ||
[[Category: Boughton-Smith | [[Category: Beaton HG]] | ||
[[Category: Cheshire | [[Category: Birkinshaw T]] | ||
[[Category: Connolly | [[Category: Boughton-Smith N]] | ||
[[Category: Cook | [[Category: Cheshire DR]] | ||
[[Category: Cooper | [[Category: Connolly S]] | ||
[[Category: Cooper | [[Category: Cook TR]] | ||
[[Category: Cox | [[Category: Cooper A]] | ||
[[Category: Dixon | [[Category: Cooper SL]] | ||
[[Category: Gensmantel | [[Category: Cox D]] | ||
[[Category: Hamley | [[Category: Dixon J]] | ||
[[Category: Harrison | [[Category: Gensmantel N]] | ||
[[Category: Hartopp | [[Category: Hamley PJ]] | ||
[[Category: Kack | [[Category: Harrison R]] | ||
[[Category: Luker | [[Category: Hartopp P]] | ||
[[Category: Mete | [[Category: Kack H]] | ||
[[Category: Millichip | [[Category: Luker T]] | ||
[[Category: Nicholls | [[Category: Mete A]] | ||
[[Category: Pimm | [[Category: Millichip I]] | ||
[[Category: St-Gallay | [[Category: Nicholls DJ]] | ||
[[Category: Wallace | [[Category: Pimm AD]] | ||
[[Category: St-Gallay SA]] | |||
[[Category: Wallace AV]] | |||
Latest revision as of 03:36, 21 November 2024
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
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