4icc: Difference between revisions
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==Crystal structure of human AKR1B10 complexed with NADP+ and JF0064== | ==Crystal structure of human AKR1B10 complexed with NADP+ and JF0064== | ||
<StructureSection load='4icc' size='340' side='right' caption='[[4icc]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='4icc' size='340' side='right'caption='[[4icc]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4icc]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4icc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ICC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ICC FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.752Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=64I:2,2,3,3,5,5,6,6-OCTAFLUOROBIPHENYL-4,4-DIOL'>64I</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4icc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4icc OCA], [https://pdbe.org/4icc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4icc RCSB], [https://www.ebi.ac.uk/pdbsum/4icc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4icc ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/AK1BA_HUMAN AK1BA_HUMAN] Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.<ref>PMID:18087047</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4icc" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4icc" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Aldo-keto reductase|Aldo-keto reductase]] | |||
*[[Aldo-keto reductase 3D structures|Aldo-keto reductase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Cousido-Siah A]] | ||
[[Category: | [[Category: Farres J]] | ||
[[Category: Klebe | [[Category: Klebe G]] | ||
[[Category: Martin MJ]] | |||
[[Category: Martin | [[Category: Mitschler A]] | ||
[[Category: Mitschler | [[Category: Pares X]] | ||
[[Category: Pares | [[Category: Podjarny A]] | ||
[[Category: Podjarny | [[Category: Porte S]] | ||
[[Category: Porte | [[Category: Ruiz FX]] | ||
[[Category: Ruiz | [[Category: De Lera AR]] | ||
[[Category: | [[Category: De la Fuente JA]] | ||
[[Category: | |||
