4kn2: Difference between revisions

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==Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed==
==Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed==
<StructureSection load='4kn2' size='340' side='right' caption='[[4kn2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4kn2' size='340' side='right'caption='[[4kn2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kn2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KN2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kn2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KN2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LYA:2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC+ACID'>LYA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4km6|4km6]], [[4km7|4km7]], [[4kmx|4kmx]], [[4kmy|4kmy]], [[4kmz|4kmz]], [[4kn0|4kn0]], [[4kn1|4kn1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LYA:2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC+ACID'>LYA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FOLR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn2 OCA], [https://pdbe.org/4kn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kn2 RCSB], [https://www.ebi.ac.uk/pdbsum/4kn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kn2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kn2 OCA], [http://pdbe.org/4kn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kn2 RCSB], [http://www.ebi.ac.uk/pdbsum/4kn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kn2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FOLR2_HUMAN FOLR2_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.  
[https://www.uniprot.org/uniprot/FOLR2_HUMAN FOLR2_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: III, C E.Dann]]
[[Category: Large Structures]]
[[Category: Wibowo, A S]]
[[Category: Dann III CE]]
[[Category: 5-methyltetrahydrofolate]]
[[Category: Wibowo AS]]
[[Category: Antifolate]]
[[Category: Folate receptor]]
[[Category: Folate receptor beta]]
[[Category: Folate-conjugate]]
[[Category: Folate]]
[[Category: Folic acid]]
[[Category: Folr2]]
[[Category: Gpi-anchored protein on eukaryotic membrane]]
[[Category: Membrane protein]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/4kn2"