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==Crystal structures of divalent metal dependent pyruvate aldolase R70A mutant, HpaI, in complex with pyruvate==
==Crystal structures of divalent metal dependent pyruvate aldolase R70A mutant, HpaI, in complex with pyruvate==
<StructureSection load='4b5w' size='340' side='right' caption='[[4b5w]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
<StructureSection load='4b5w' size='340' side='right'caption='[[4b5w]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4b5w]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecolc Ecolc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B5W FirstGlance]. <br>
<table><tr><td colspan='2'>[[4b5w]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_ATCC_8739 Escherichia coli ATCC 8739]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B5W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.792&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b5s|4b5s]], [[4b5t|4b5t]], [[4b5u|4b5u]], [[4b5v|4b5v]], [[4b5x|4b5x]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-dehydro-3-deoxyglucarate_aldolase 2-dehydro-3-deoxyglucarate aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.20 4.1.2.20] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b5w OCA], [https://pdbe.org/4b5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b5w RCSB], [https://www.ebi.ac.uk/pdbsum/4b5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b5w ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b5w OCA], [http://pdbe.org/4b5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b5w RCSB], [http://www.ebi.ac.uk/pdbsum/4b5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b5w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HPCH_ECOLC HPCH_ECOLC]] Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.[HAMAP-Rule:MF_01292]  
[https://www.uniprot.org/uniprot/HPCH_ECOLC HPCH_ECOLC] Catalyzes the reversible retro-aldol cleavage of 4-hydroxy-2-ketoheptane-1,7-dioate (HKHD) to pyruvate and succinic semialdehyde.[HAMAP-Rule:MF_01292]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Aldolase|Aldolase]]
*[[Aldolase 3D structures|Aldolase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2-dehydro-3-deoxyglucarate aldolase]]
[[Category: Escherichia coli ATCC 8739]]
[[Category: Ecolc]]
[[Category: Large Structures]]
[[Category: Coincon, M]]
[[Category: Coincon M]]
[[Category: Seah, S Y.K]]
[[Category: Seah SYK]]
[[Category: Sygusch, J]]
[[Category: Sygusch J]]
[[Category: Wang, W]]
[[Category: Wang W]]
[[Category: Lyase]]
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