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==Crystal structure of DENV1-E111 single chain variable fragment bound to DENV-1 DIII, strain 16007.==
==Crystal structure of DENV1-E111 single chain variable fragment bound to DENV-1 DIII, strain 16007.==
<StructureSection load='4ffy' size='340' side='right' caption='[[4ffy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4ffy' size='340' side='right'caption='[[4ffy]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ffy]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FFY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ffy]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FFY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3irc|3irc]], [[4ffz|4ffz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Envelope domain III ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11053 Dengue virus 1])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ffy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffy OCA], [https://pdbe.org/4ffy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ffy RCSB], [https://www.ebi.ac.uk/pdbsum/4ffy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ffy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ffy OCA], [http://pdbe.org/4ffy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ffy RCSB], [http://www.ebi.ac.uk/pdbsum/4ffy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ffy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/Q9J7C6_9FLAV Q9J7C6_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Dengue virus 1]]
[[Category: Dengue virus 1]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Austin, S K]]
[[Category: Mus musculus]]
[[Category: Structural genomic]]
[[Category: Austin SK]]
[[Category: Fremont, D H]]
[[Category: Fremont DH]]
[[Category: Nelson, C A]]
[[Category: Nelson CA]]
[[Category: Antibody epitope]]
[[Category: Csgid]]
[[Category: Dengue virus]]
[[Category: Flavivirus]]
[[Category: Immune system]]
[[Category: Immune system-viral protein complex]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Viral envelope protein]]
Retrieved from "https://proteopedia.org/4ffy"