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==Crystal structure of the TSG101 UEV domain in complex with FA459 peptide==
==Crystal structure of the TSG101 UEV domain in complex with FA459 peptide==
<StructureSection load='3p9g' size='340' side='right' caption='[[3p9g]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='3p9g' size='340' side='right'caption='[[3p9g]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3p9g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P9G FirstGlance]. <br>
<table><tr><td colspan='2'>[[3p9g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P9G FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZYK:(4R)-4-({[(3,4-DIMETHOXYPHENYL)CARBONYL]AMINO}OXY)-L-PROLINE'>ZYK</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3obq|3obq]], [[3p9h|3p9h]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZYK:(4R)-4-({[(3,4-DIMETHOXYPHENYL)CARBONYL]AMINO}OXY)-L-PROLINE'>ZYK</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TSG101 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p9g OCA], [https://pdbe.org/3p9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p9g RCSB], [https://www.ebi.ac.uk/pdbsum/3p9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p9g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p9g OCA], [http://pdbe.org/3p9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3p9g RCSB], [http://www.ebi.ac.uk/pdbsum/3p9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3p9g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> [[http://www.uniprot.org/uniprot/Q9YP46_9HIV1 Q9YP46_9HIV1]] Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).[SAAS:SAAS012344_004_008806]  Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity).[SAAS:SAAS012344_004_011858]
[https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Gag polyprotein|Gag polyprotein]]
*[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]]
*[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Hurley, J H]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Im, Y J]]
[[Category: Large Structures]]
[[Category: Protein transport]]
[[Category: Hurley JH]]
[[Category: Ubiquitin]]
[[Category: Im YJ]]

Latest revision as of 09:50, 6 September 2023

Crystal structure of the TSG101 UEV domain in complex with FA459 peptide

3p9g, resolution 1.80Å

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