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==Structure and function of the N-terminal nucleolin binding domain of nuclear valocine containing protein like 2 (NVL2) harboring a nucleolar localization signal==
==Structure and function of the N-terminal nucleolin binding domain of nuclear valocine containing protein like 2 (NVL2) harboring a nucleolar localization signal==
<StructureSection load='2rre' size='340' side='right' caption='[[2rre]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2rre' size='340' side='right'caption='[[2rre]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rre]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2RRE FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rre]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRE FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rre OCA], [http://pdbe.org/2rre PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2rre RCSB], [http://www.ebi.ac.uk/pdbsum/2rre PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2rre ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rre OCA], [https://pdbe.org/2rre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rre RCSB], [https://www.ebi.ac.uk/pdbsum/2rre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rre ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NVL_MOUSE NVL_MOUSE] Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.[UniProtKB:O15381]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Fujiwara, K]]
[[Category: Mus musculus]]
[[Category: Fujiwara, Y]]
[[Category: Fujiwara K]]
[[Category: Goda, N]]
[[Category: Fujiwara Y]]
[[Category: Hiroaki, H]]
[[Category: Goda N]]
[[Category: Iwaya, N]]
[[Category: Hiroaki H]]
[[Category: Shirakawa, M]]
[[Category: Iwaya N]]
[[Category: Tenno, T]]
[[Category: Shirakawa M]]
[[Category: Alternatively spliced domain]]
[[Category: Tenno T]]
[[Category: Nuclear protein]]
[[Category: Nucleolar localization signal]]
[[Category: Rna binding]]