3uyi: Difference between revisions
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==Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding== | ==Crystal Structure of Perakine Reductase, Founder Member of a Novel AKR Subfamily with Unique Conformational Changes during NADPH Binding== | ||
<StructureSection load='3uyi' size='340' side='right' caption='[[3uyi]], [[Resolution|resolution]] 2.31Å' scene=''> | <StructureSection load='3uyi' size='340' side='right'caption='[[3uyi]], [[Resolution|resolution]] 2.31Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3uyi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UYI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UYI FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.313Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uyi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uyi OCA], [https://pdbe.org/3uyi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uyi RCSB], [https://www.ebi.ac.uk/pdbsum/3uyi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uyi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PERR_RAUSE PERR_RAUSE] Aldo-keto reductase involved in the biosynthesis of monoterpenoid indole alkaloids. Broad substrate specificity enzyme with a high selectivity in the group of alkaloids. Can use perakine, 19(S),20(R)-dihydro-peraksine-17,21-al, cinnamic aldehyde, p-coumaric aldehyde and 3-(3,4,5-trimethoxyphenyl)propanal as substrates, but not ketosteroids such as progesterone. NADPH could not be replaced by NADH.<ref>PMID:18409028</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Chen | [[Category: Rauvolfia serpentina]] | ||
[[Category: Mindnich | [[Category: Chen Y]] | ||
[[Category: Mueller | [[Category: Mindnich R]] | ||
[[Category: Panjikar | [[Category: Mueller U]] | ||
[[Category: Penning | [[Category: Panjikar S]] | ||
[[Category: Rajendran | [[Category: Penning TM]] | ||
[[Category: Rosenthal | [[Category: Rajendran C]] | ||
[[Category: Stoeckigt | [[Category: Rosenthal C]] | ||
[[Category: Sun | [[Category: Stoeckigt J]] | ||
[[Category: Wang | [[Category: Sun L]] | ||
[[Category: Wang M]] | |||
