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==Crystal structure of dimethylsulphoniopropionate (DMSP) lyase DddQ Y131A in complex with DMSP==
==Crystal structure of dimethylsulphoniopropionate (DMSP) lyase DddQ Y131A in complex with DMSP==
<StructureSection load='4la3' size='340' side='right' caption='[[4la3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4la3' size='340' side='right'caption='[[4la3]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4la3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Silicibacter_lacuscaerulensis_dsm_11314 Silicibacter lacuscaerulensis dsm 11314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LA3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4la3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ruegeria_lacuscaerulensis_ITI-1157 Ruegeria lacuscaerulensis ITI-1157]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LA3 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DQY:3-(DIMETHYL-LAMBDA~4~-SULFANYL)PROPANOIC+ACID'>DQY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.701&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4la2|4la2]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DQY:3-(DIMETHYL-LAMBDA~4~-SULFANYL)PROPANOIC+ACID'>DQY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SL1157_0332 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=644107 Silicibacter lacuscaerulensis DSM 11314])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4la3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la3 OCA], [https://pdbe.org/4la3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4la3 RCSB], [https://www.ebi.ac.uk/pdbsum/4la3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4la3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4la3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4la3 OCA], [http://pdbe.org/4la3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4la3 RCSB], [http://www.ebi.ac.uk/pdbsum/4la3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4la3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DDDQ_RUELI DDDQ_RUELI] Able to cleave dimethlysulfonioproprionate (DMSP) in vitro, releasing dimethyl sulfide (DMS). DMS is the principal form by which sulfur is transported from oceans to the atmosphere (PubMed:24395783, PubMed:24967457). The real activity of the protein is however subject to debate and it is unclear whether it constitutes a real dimethlysulfonioproprionate lyase in vivo: the very low activity with DMSP as substrate suggests that DMSP is not its native substrate (PubMed:24760823).<ref>PMID:24395783</ref> <ref>PMID:24760823</ref> <ref>PMID:24967457</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Silicibacter lacuscaerulensis dsm 11314]]
[[Category: Large Structures]]
[[Category: Li, C]]
[[Category: Ruegeria lacuscaerulensis ITI-1157]]
[[Category: Zhang, Y]]
[[Category: Li C]]
[[Category: Cupin motif]]
[[Category: Zhang Y]]
[[Category: Dmsp lyase]]
[[Category: Lyase]]
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