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==Crystal structure of Myo5a globular tail domain in complex with melanophilin GTBD==
==Crystal structure of Myo5a globular tail domain in complex with melanophilin GTBD==
<StructureSection load='4lx2' size='340' side='right' caption='[[4lx2]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='4lx2' size='340' side='right'caption='[[4lx2]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4lx2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LX2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LX2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4lx2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LX2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lwz|4lwz]], [[4lx0|4lx0]], [[4lx1|4lx1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYO5A, MYH12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lx2 OCA], [https://pdbe.org/4lx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lx2 RCSB], [https://www.ebi.ac.uk/pdbsum/4lx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lx2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lx2 OCA], [http://pdbe.org/4lx2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lx2 RCSB], [http://www.ebi.ac.uk/pdbsum/4lx2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lx2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN] Griscelli disease type 3;Neuroectodermal melanolysosomal disease;Griscelli disease type 1. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN]] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref> [[http://www.uniprot.org/uniprot/MELPH_MOUSE MELPH_MOUSE]] Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A.<ref>PMID:11887186</ref> 
[https://www.uniprot.org/uniprot/MYO5A_HUMAN MYO5A_HUMAN] Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.<ref>PMID:10448864</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Myosin|Myosin]]
*[[Exophilin 3D structures|Exophilin 3D structures]]
*[[Myosin 3D Structures|Myosin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Attanda, W]]
[[Category: Large Structures]]
[[Category: Gauquelin, C]]
[[Category: Mus musculus]]
[[Category: Houdusse, A]]
[[Category: Attanda W]]
[[Category: Pylypenko, O]]
[[Category: Gauquelin C]]
[[Category: Contractile protein-protein transport complex]]
[[Category: Houdusse A]]
[[Category: Dil]]
[[Category: Pylypenko O]]
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