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==CRYSTAL STRUCTURE OF THE HUMAN DERIVED SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) 9004G IN COMPLEX WITH CN2 TOXIN FROM THE SCORPION CENTRUROIDES NOXIUS HOFFMANN==
==Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann==
<StructureSection load='2yc1' size='340' side='right' caption='[[2yc1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2yc1' size='340' side='right'caption='[[2yc1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yc1]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Cenno Cenno] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YC1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yc1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_noxius Centruroides noxius] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YC1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cn2|1cn2]], [[2ybr|2ybr]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yc1 OCA], [http://pdbe.org/2yc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yc1 RCSB], [http://www.ebi.ac.uk/pdbsum/2yc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yc1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yc1 OCA], [https://pdbe.org/2yc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yc1 RCSB], [https://www.ebi.ac.uk/pdbsum/2yc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yc1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SCX2_CENNO SCX2_CENNO]] Mammal beta-toxins bind voltage-independently at site-4 of sodium channels and shift the activation voltage to more negative potentials. This toxin is active against mammals.  
[https://www.uniprot.org/uniprot/SCX2_CENNO SCX2_CENNO] Mammal beta-toxins bind voltage-independently at site-4 of sodium channels and shift the activation voltage to more negative potentials. This toxin is active against mammals.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[3D structures of monoclonal antibody|3D structures of monoclonal antibody]]
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cenno]]
[[Category: Centruroides noxius]]
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Becerril, B]]
[[Category: Large Structures]]
[[Category: Canul-Tec, J C]]
[[Category: Becerril B]]
[[Category: Possani, L D]]
[[Category: Canul-Tec JC]]
[[Category: Riano-Umbarila, L]]
[[Category: Possani LD]]
[[Category: Rudino-Pinera, E]]
[[Category: Riano-Umbarila L]]
[[Category: Torres-Larios, A]]
[[Category: Rudino-Pinera E]]
[[Category: Immune system-toxin complex]]
[[Category: Torres-Larios A]]
[[Category: Scorpion toxin]]
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