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==Tetracycline repressor class D mutant H100A in complex with iso-7- Chlortetracycline==
==Tetracycline repressor class D mutant H100A in complex with iso-7- Chlortetracycline==
<StructureSection load='4b1r' size='340' side='right' caption='[[4b1r]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4b1r' size='340' side='right'caption='[[4b1r]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4b1r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B1R FirstGlance]. <br>
<table><tr><td colspan='2'>[[4b1r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B1R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B1R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ITC:ISO-7-CHLORTETRACYCLINE'>ITC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a6i|1a6i]], [[1bj0|1bj0]], [[1bjy|1bjy]], [[1bjz|1bjz]], [[1du7|1du7]], [[1ork|1ork]], [[1qpi|1qpi]], [[2tct|2tct]], [[2trt|2trt]], [[2vke|2vke]], [[2vkv|2vkv]], [[2x6o|2x6o]], [[2x9d|2x9d]], [[2xb5|2xb5]], [[2xgc|2xgc]], [[2xgd|2xgd]], [[2xge|2xge]], [[2xps|2xps]], [[2xpt|2xpt]], [[2xpu|2xpu]], [[2xpv|2xpv]], [[2xpw|2xpw]], [[2xrl|2xrl]], [[3zqf|3zqf]], [[3zqg|3zqg]], [[3zqh|3zqh]], [[3zqi|3zqi]], [[4abz|4abz]], [[4aux|4aux]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ITC:ISO-7-CHLORTETRACYCLINE'>ITC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1r OCA], [http://pdbe.org/4b1r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b1r RCSB], [http://www.ebi.ac.uk/pdbsum/4b1r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b1r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b1r OCA], [https://pdbe.org/4b1r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b1r RCSB], [https://www.ebi.ac.uk/pdbsum/4b1r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b1r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX]] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.  
[https://www.uniprot.org/uniprot/TETR4_ECOLX TETR4_ECOLX] TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.


==See Also==
==See Also==
*[[Tetracycline repressor protein|Tetracycline repressor protein]]
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Eltschkner, S]]
[[Category: Large Structures]]
[[Category: Hinrichs, W]]
[[Category: Eltschkner S]]
[[Category: Palm, G J]]
[[Category: Hinrichs W]]
[[Category: Schneider, J]]
[[Category: Palm GJ]]
[[Category: Iso-tetracycline]]
[[Category: Schneider J]]
[[Category: Transcription]]

Latest revision as of 11:41, 20 December 2023

Tetracycline repressor class D mutant H100A in complex with iso-7- Chlortetracycline

4b1r, resolution 1.95Å

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