3l0r: Difference between revisions

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==Crystal Structure of Salivary Cystatin from the Soft Tick Ornithodoros moubata==
==Crystal Structure of Salivary Cystatin from the Soft Tick Ornithodoros moubata==
<StructureSection load='3l0r' size='340' side='right' caption='[[3l0r]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='3l0r' size='340' side='right'caption='[[3l0r]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Argasid_tick Argasid tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L0R FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L0R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OmC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6938 Argasid tick])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l0r OCA], [http://pdbe.org/3l0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l0r RCSB], [http://www.ebi.ac.uk/pdbsum/3l0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l0r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l0r OCA], [https://pdbe.org/3l0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l0r RCSB], [https://www.ebi.ac.uk/pdbsum/3l0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l0r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CYS2_ORNMO CYS2_ORNMO] Inhibitor of cysteine proteinases with broad specificity for mammalian cathepsins, including endopeptidases (cathepsins L and S) and exopeptidases (cathepsins B, C and H) (PubMed:17132111, PubMed:20545626). Also inhibits endogenous cathepsin B-like and cathepsin C-like proteinases (PubMed:17132111). Does not inhibit human legumain (PubMed:20545626). May mimic specific host-derived cystatin(s) to interfere with its/their function in controlling cathepsin-mediated proteolysis (PubMed:20545626). Affects the function of antigen-presenting mouse dendritic cells by reducing the production of the pro-inflammatory cytokines TNF and interleukin-12, and proliferation of antigen-specific CD4+ T-cells, suggesting it may suppress the host adaptive immune response (PubMed:20545626). It is noteworthy that immunization of mice with this protein reduces O.moubata survival in infestation experiments (PubMed:20545626).<ref>PMID:17132111</ref> <ref>PMID:20545626</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l0r_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l0r_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Argasid tick]]
[[Category: Large Structures]]
[[Category: Andersen, J F]]
[[Category: Ornithodoros moubata]]
[[Category: Brynda, J]]
[[Category: Andersen JF]]
[[Category: Kovarova, Z]]
[[Category: Brynda J]]
[[Category: Mares, M]]
[[Category: Kovarova Z]]
[[Category: Rezacova, P]]
[[Category: Mares M]]
[[Category: Salat, J]]
[[Category: Rezacova P]]
[[Category: Cystatin]]
[[Category: Salat J]]
[[Category: Hydrolase inhibitor]]
[[Category: Protease inhibitor]]
[[Category: Soft tick]]
[[Category: Thiol protease inhibitor]]
Retrieved from "https://proteopedia.org/3l0r"