4ad6: Difference between revisions

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==Synthesis and SAR of guanine based analogues for HPPK inhibitors==
==Synthesis and SAR of guanine based analogues for HPPK inhibitors==
<StructureSection load='4ad6' size='340' side='right' caption='[[4ad6]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='4ad6' size='340' side='right'caption='[[4ad6]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ad6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AD6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ad6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AD6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSY:7-(2-HYDROXYETHYL)-8-MERCAPTOGUANINE'>GSY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSY:7-(2-HYDROXYETHYL)-8-MERCAPTOGUANINE'>GSY</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ad6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ad6 OCA], [http://pdbe.org/4ad6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ad6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ad6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ad6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ad6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ad6 OCA], [https://pdbe.org/4ad6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ad6 RCSB], [https://www.ebi.ac.uk/pdbsum/4ad6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ad6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H3JKY1_STAAN A0A0H3JKY1_STAAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]
[[Category: Large Structures]]
[[Category: Chhabra, S]]
[[Category: Staphylococcus aureus]]
[[Category: Peat, T S]]
[[Category: Chhabra S]]
[[Category: Swarbrick, J]]
[[Category: Peat TS]]
[[Category: Spr]]
[[Category: Swarbrick J]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4ad6"