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==Crystal Structure of M11, the BCL-2 Homolog of Murine Gamma-herpesvirus 68, Complexed with Mouse Beclin1 (residues 106-124)==
==Crystal Structure of M11, the BCL-2 Homolog of Murine Gamma-herpesvirus 68, Complexed with Mouse Beclin1 (residues 106-124)==
<StructureSection load='3bl2' size='340' side='right' caption='[[3bl2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3bl2' size='340' side='right'caption='[[3bl2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3bl2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Mhv68 Mhv68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BL2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BL2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3bl2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Murid_gammaherpesvirus_4 Murid gammaherpesvirus 4] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BL2 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">v-bcl-2, GAMMAHV.M11, M11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33708 MHV68]), Becn1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bl2 OCA], [http://pdbe.org/3bl2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bl2 RCSB], [http://www.ebi.ac.uk/pdbsum/3bl2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bl2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bl2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bl2 OCA], [https://pdbe.org/3bl2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bl2 RCSB], [https://www.ebi.ac.uk/pdbsum/3bl2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bl2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BECN1_MOUSE BECN1_MOUSE]] Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense.<ref>PMID:10604474</ref> <ref>PMID:12372286</ref> <ref>PMID:19270693</ref>
[https://www.uniprot.org/uniprot/ARBH_MHV68 ARBH_MHV68] Plays a role in the protection against apoptosis mediated by cytotoxic cells during the immune response to acute and persistent viral infection. Contributes therefore to latency establishment. Plays also a role in the inhibition of host starvation-induced autophagy which ultimately contributes to the viral chronic infection.<ref>PMID:10573168</ref> <ref>PMID:11205127</ref> <ref>PMID:15604429</ref> <ref>PMID:18248095</ref> <ref>PMID:18797192</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Bcl-2|Bcl-2]]
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Mhv68]]
[[Category: Murid gammaherpesvirus 4]]
[[Category: Ku, B]]
[[Category: Mus musculus]]
[[Category: Oh, B H]]
[[Category: Ku B]]
[[Category: Woo, J S]]
[[Category: Oh B-H]]
[[Category: Antiviral defense]]
[[Category: Woo J-S]]
[[Category: Apoptosis]]
[[Category: Autophagy]]
[[Category: Beclin1]]
[[Category: Golgi apparatus]]
[[Category: M11]]
[[Category: Membrane]]
[[Category: Protein-protein complex]]
[[Category: Viral bcl-2]]
[[Category: Viral protein-apoptosis complex]]
Retrieved from "https://proteopedia.org/3bl2"