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==Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain==
==Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain==
<StructureSection load='3oj8' size='340' side='right' caption='[[3oj8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='3oj8' size='340' side='right'caption='[[3oj8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3oj8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OJ8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OJ8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3oj8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OJ8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OJ8:(S)-[(2S)-6-PHENOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL](5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)METHANOL'>OJ8</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wj1|2wj1]], [[2wj2|2wj2]], [[2vya|2vya]], [[3lj6|3lj6]], [[2wap|2wap]], [[3k7f|3k7f]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OJ8:(S)-[(2S)-6-PHENOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL](5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)METHANOL'>OJ8</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Faah, faah-1, Faah1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oj8 OCA], [https://pdbe.org/3oj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oj8 RCSB], [https://www.ebi.ac.uk/pdbsum/3oj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oj8 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fatty_acid_amide_hydrolase Fatty acid amide hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.99 3.5.1.99] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oj8 OCA], [http://pdbe.org/3oj8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3oj8 RCSB], [http://www.ebi.ac.uk/pdbsum/3oj8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3oj8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT]] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Fatty acid amide hydrolase]]
[[Category: Rattus norvegicus]]
[[Category: Boger, D L]]
[[Category: Boger DL]]
[[Category: Mileni, M]]
[[Category: Mileni M]]
[[Category: Stevens, R C]]
[[Category: Stevens RC]]
[[Category: Enantiomer]]
[[Category: Faah]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Membrane]]
[[Category: Oxazole]]
[[Category: Protein-inhibitor complex]]
[[Category: Serine hydrolase]]
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