3w9j: Difference between revisions

<StructureSection load='3w9j' size='340' side='right'caption='[[3w9j]], [[Resolution|resolution]] 3.15&Aring;' scene=''>

<table><tr><td colspan='2'>[[3w9j]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W9J FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=P9D:[{2-[({[(3R)-1-{8-[(4-TERT-BUTYL-1,3-THIAZOL-2-YL)CARBAMOYL]-4-OXO-3-[(E)-2-(1H-TETRAZOL-5-YL)ETHENYL]-4H-PYRIDO[1,2-A]PYRIMIDIN-2-YL}PIPERIDIN-3-YL]OXY}CARBONYL)AMINO]ETHYL}(DIMETHYL)AMMONIO]ACETATE'>P9D</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w9j OCA], [https://pdbe.org/3w9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w9j RCSB], [https://www.ebi.ac.uk/pdbsum/3w9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w9j ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/MEXB_PSEAE MEXB_PSEAE] The inner membrane transporter component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Implicated in the secretion of the siderophore pyoverdine.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9603892</ref>  

[[Category: Large Structures]]

[[Category: Pseudomonas aeruginosa PAO1]]

[[Category: Hayashi K]]

[[Category: Nakashima R]]

[[Category: Sakurai K]]

[[Category: Yamaguchi A]]