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==crystal structure of the Sec7 domain from human cytohesin1==
==crystal structure of the Sec7 domain from human cytohesin1==
<StructureSection load='4a4p' size='340' side='right' caption='[[4a4p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4a4p' size='340' side='right'caption='[[4a4p]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a4p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A4P FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a4p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A4P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bc9|1bc9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4p OCA], [http://pdbe.org/4a4p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a4p RCSB], [http://www.ebi.ac.uk/pdbsum/4a4p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a4p OCA], [https://pdbe.org/4a4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a4p RCSB], [https://www.ebi.ac.uk/pdbsum/4a4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a4p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CYH1_HUMAN CYH1_HUMAN]] Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.<ref>PMID:10652308</ref> <ref>PMID:9653114</ref>
[https://www.uniprot.org/uniprot/CYH1_HUMAN CYH1_HUMAN] Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.<ref>PMID:10652308</ref> <ref>PMID:9653114</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Biou, V]]
[[Category: Large Structures]]
[[Category: Cherfils, J]]
[[Category: Biou V]]
[[Category: Thompson, A W]]
[[Category: Cherfils J]]
[[Category: Zeeh, J C]]
[[Category: Thompson AW]]
[[Category: All alpha]]
[[Category: Zeeh JC]]
[[Category: Guanine-nucleotide releasing factor]]
[[Category: Signaling protein]]

Latest revision as of 11:19, 20 December 2023

crystal structure of the Sec7 domain from human cytohesin1

4a4p, resolution 2.00Å

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