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==CRYSTAL STRUCTURE OF LEISHMANIA INFANTUM TRYPANOTHIONE REDUCTASE IN COMPLEX WITH NADPH AND TRYPANOTHIONE==
==CRYSTAL STRUCTURE OF LEISHMANIA INFANTUM TRYPANOTHIONE REDUCTASE IN COMPLEX WITH NADPH AND TRYPANOTHIONE==
<StructureSection load='4adw' size='340' side='right' caption='[[4adw]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
<StructureSection load='4adw' size='340' side='right'caption='[[4adw]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4adw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leiin Leiin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ADW FirstGlance]. <br>
<table><tr><td colspan='2'>[[4adw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_infantum Leishmania infantum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ADW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ADW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GCG:BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE'>GCG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.61&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jk6|2jk6]], [[2w0h|2w0h]], [[2x50|2x50]], [[2yau|2yau]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GCG:BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE'>GCG</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypanothione-disulfide_reductase Trypanothione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.12 1.8.1.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4adw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4adw OCA], [https://pdbe.org/4adw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4adw RCSB], [https://www.ebi.ac.uk/pdbsum/4adw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4adw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4adw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4adw OCA], [http://pdbe.org/4adw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4adw RCSB], [http://www.ebi.ac.uk/pdbsum/4adw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4adw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A4HSF7_LEIIN A4HSF7_LEIIN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Leiin]]
[[Category: Large Structures]]
[[Category: Trypanothione-disulfide reductase]]
[[Category: Leishmania infantum]]
[[Category: Baiocco, P]]
[[Category: Baiocco P]]
[[Category: Colotti, G]]
[[Category: Colotti G]]
[[Category: Fiorillo, A]]
[[Category: Fiorillo A]]
[[Category: Ilari, A]]
[[Category: Ilari A]]
[[Category: Malatesta, F]]
[[Category: Malatesta F]]
[[Category: Inhibition mechanism]]
[[Category: Oxidoreductase]]

Latest revision as of 11:24, 20 December 2023

CRYSTAL STRUCTURE OF LEISHMANIA INFANTUM TRYPANOTHIONE REDUCTASE IN COMPLEX WITH NADPH AND TRYPANOTHIONE

4adw, resolution 3.61Å

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