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[[Image:1ldg.gif|left|200px]]


{{Structure
==PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE==
|PDB= 1ldg |SIZE=350|CAPTION= <scene name='initialview01'>1ldg</scene>, resolution 1.74&Aring;
<StructureSection load='1ldg' size='340' side='right'caption='[[1ldg]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene>
<table><tr><td colspan='2'>[[1ldg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LDG FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ldg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ldg OCA], [https://pdbe.org/1ldg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ldg RCSB], [https://www.ebi.ac.uk/pdbsum/1ldg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ldg ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ldg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ldg OCA], [http://www.ebi.ac.uk/pdbsum/1ldg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ldg RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/LDH_PLAFD LDH_PLAFD]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/1ldg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ldg ConSurf].
<div style="clear:both"></div>


'''PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE'''
==See Also==
 
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1LDG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LDG OCA].
[[Category: Large Structures]]
 
==Reference==
The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design., Dunn CR, Banfield MJ, Barker JJ, Higham CW, Moreton KM, Turgut-Balik D, Brady RL, Holbrook JJ, Nat Struct Biol. 1996 Nov;3(11):912-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8901865 8901865]
[[Category: L-lactate dehydrogenase]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
[[Category: Single protein]]
[[Category: Banfield M]]
[[Category: Banfield, M.]]
[[Category: Barker J]]
[[Category: Barker, J.]]
[[Category: Brady L]]
[[Category: Brady, L.]]
[[Category: Dunn C]]
[[Category: Dunn, C.]]
[[Category: Higham C]]
[[Category: Higham, C.]]
[[Category: Holbrook JJ]]
[[Category: Holbrook, J J.]]
[[Category: Moreton K]]
[[Category: Moreton, K.]]
[[Category: Turgut-Balik D]]
[[Category: Turgut-Balik, D.]]
[[Category: nad]]
[[Category: oxidoreductase]]
[[Category: tricarboxylic acid cycle]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:01:25 2008''

Latest revision as of 07:32, 14 February 2024

PLASMODIUM FALCIPARUM L-LACTATE DEHYDROGENASE COMPLEXED WITH NADH AND OXAMATE

1ldg, resolution 1.74Å

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