4c5e: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:


==Crystal structure of the minimal Pho-Sfmbt complex (P21 spacegroup)==
==Crystal structure of the minimal Pho-Sfmbt complex (P21 spacegroup)==
<StructureSection load='4c5e' size='340' side='right' caption='[[4c5e]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4c5e' size='340' side='right'caption='[[4c5e]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c5e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C5E FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c5e]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C5E FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c5g|4c5g]], [[4c5h|4c5h]], [[4c5i|4c5i]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.951&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5e OCA], [http://pdbe.org/4c5e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c5e RCSB], [http://www.ebi.ac.uk/pdbsum/4c5e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c5e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c5e OCA], [https://pdbe.org/4c5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c5e RCSB], [https://www.ebi.ac.uk/pdbsum/4c5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c5e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SMBT_DROME SMBT_DROME]] Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:16618800</ref> [[http://www.uniprot.org/uniprot/PHO_DROME PHO_DROME]] Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:9651589</ref> <ref>PMID:10433918</ref>  Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity).<ref>PMID:9651589</ref> <ref>PMID:10433918</ref> 
[https://www.uniprot.org/uniprot/SMBT_DROME SMBT_DROME] Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.<ref>PMID:16618800</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 18: Line 18:
</div>
</div>
<div class="pdbe-citations 4c5e" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4c5e" style="background-color:#fffaf0;"></div>
==See Also==
*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Drome]]
[[Category: Drosophila melanogaster]]
[[Category: Alfieri, C]]
[[Category: Large Structures]]
[[Category: Glatt, S]]
[[Category: Alfieri C]]
[[Category: Mueller, C W]]
[[Category: Glatt S]]
[[Category: Transcription]]
[[Category: Mueller CW]]
Retrieved from "https://proteopedia.org/4c5e"