2wfm: Difference between revisions
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== | ==Crystal structure of polyneuridine aldehyde esterase mutant (H244A)== | ||
<StructureSection load='2wfm' size='340' side='right' caption='[[2wfm]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='2wfm' size='340' side='right'caption='[[2wfm]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2wfm]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WFM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wfm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wfm OCA], [https://pdbe.org/2wfm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wfm RCSB], [https://www.ebi.ac.uk/pdbsum/2wfm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wfm ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PNAE_RAUSE PNAE_RAUSE] Catalyzes the hydrolysis of polyneuridine aldehyde into epi-vellosimine, which is the immediate precursor for the synthesis of the ajmaline.<ref>PMID:10691977</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfm_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/2wfm_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 36: | Line 35: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rauvolfia serpentina]] | ||
[[Category: Hill | [[Category: Hill M]] | ||
[[Category: Panjikar | [[Category: Panjikar S]] | ||
[[Category: Stoeckigt | [[Category: Stoeckigt J]] | ||
[[Category: Wang | [[Category: Wang M]] | ||
[[Category: Yang | [[Category: Yang L]] | ||
Latest revision as of 15:54, 13 December 2023
Crystal structure of polyneuridine aldehyde esterase mutant (H244A)
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