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==Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 2mM Bromide==
==Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 2mM Bromide==
<StructureSection load='4kk9' size='340' side='right' caption='[[4kk9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4kk9' size='340' side='right'caption='[[4kk9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kk9]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KK9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kk9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KK9 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kk5|4kk5]], [[4kk6|4kk6]], [[4kk8|4kk8]], [[4kjw|4kjw]], [[4kka|4kka]], [[4kkb|4kkb]], [[4kkc|4kkc]], [[4kjp|4kjp]], [[4kjq|4kjq]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.997&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0155, clcA, eriC, JW5012, yadQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk9 OCA], [https://pdbe.org/4kk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kk9 RCSB], [https://www.ebi.ac.uk/pdbsum/4kk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kk9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk9 OCA], [http://pdbe.org/4kk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/4kk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kk9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CLCA_ECOLI CLCA_ECOLI]] Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.<ref>PMID:12384697</ref> <ref>PMID:14985752</ref> <ref>PMID:16341087</ref> <ref>PMID:16905147</ref> <ref>PMID:18678918</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Lim, H H]]
[[Category: Mus musculus]]
[[Category: Miller, C]]
[[Category: Lim H-H]]
[[Category: Membrane transporter]]
[[Category: Miller C]]
[[Category: Transport protein]]

Latest revision as of 03:09, 21 November 2024

Structure of the E148A mutant of CLC-ec1 deltaNC construct in 100mM fluoride and 2mM Bromide

4kk9, resolution 3.00Å

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