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==Crystal Structure of an Evolved Replicating DNA Polymerase==
==Crystal Structure of an Evolved Replicating DNA Polymerase==
<StructureSection load='4ahc' size='340' side='right' caption='[[4ahc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4ahc' size='340' side='right'caption='[[4ahc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ahc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AHC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ahc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AHC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jgu|2jgu]], [[4ail|4ail]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ahc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahc OCA], [https://pdbe.org/4ahc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ahc RCSB], [https://www.ebi.ac.uk/pdbsum/4ahc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ahc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahc OCA], [http://pdbe.org/4ahc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ahc RCSB], [http://www.ebi.ac.uk/pdbsum/4ahc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DPOL_PYRFU DPOL_PYRFU]] In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.  
[https://www.uniprot.org/uniprot/DPOL_PYRFU DPOL_PYRFU] In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 43587]]
[[Category: Large Structures]]
[[Category: DNA-directed DNA polymerase]]
[[Category: Pyrococcus furiosus]]
[[Category: Holliger, P]]
[[Category: Holliger P]]
[[Category: Leslie, A G.W]]
[[Category: Leslie AGW]]
[[Category: Wynne, S A]]
[[Category: Wynne SA]]
[[Category: Apoenzyme]]
[[Category: B family polymerase]]
[[Category: Transferase]]
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