3m9a: Difference between revisions

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==Protein structure of type III plasmid segregation TubR==
==Protein structure of type III plasmid segregation TubR==
<StructureSection load='3m9a' size='340' side='right' caption='[[3m9a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3m9a' size='340' side='right'caption='[[3m9a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3m9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacti Bacti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M9A FirstGlance]. <br>
<table><tr><td colspan='2'>[[3m9a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis_serovar_israelensis Bacillus thuringiensis serovar israelensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M9A FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3m8e|3m8e]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pBt157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1430 BACTI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m9a OCA], [https://pdbe.org/3m9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m9a RCSB], [https://www.ebi.ac.uk/pdbsum/3m9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m9a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m9a OCA], [http://pdbe.org/3m9a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m9a RCSB], [http://www.ebi.ac.uk/pdbsum/3m9a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m9a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TUBR_BACTI TUBR_BACTI] A DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid. Cooperatively binds to the centromere-like site (tubC), which may seed filament formation by the TubZ polymerizing GTPase, stabilizing TubZ filaments. TubR-tubC complexes track the depolymerizing minus end of the filament, probably pulling plasmid within the cell (PubMed:20534443, PubMed:23010931, PubMed:25825718). Required for plasmid replication (PubMed:16936050, PubMed:17873046). Negatively regulates levels of TubZ; its effect on RNA expression has not been shown (Probable). Specifically binds iterons, 12-bp imperfect direct repeats that function as a plasmid origin of replication (PubMed:17873046, PubMed:23010931, PubMed:25825718). Four TubR dimers bind to tubC, forming an extended bent DNA-protein filament with protein wrapping helically around the outside of the DNA (PubMed:20534443, PubMed:23010931).<ref>PMID:16936050</ref> <ref>PMID:17873046</ref> <ref>PMID:20534443</ref> <ref>PMID:23010931</ref> <ref>PMID:25825718</ref> <ref>PMID:17510284</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacti]]
[[Category: Bacillus thuringiensis serovar israelensis]]
[[Category: Ni, L]]
[[Category: Large Structures]]
[[Category: Schumacher, M A]]
[[Category: Ni L]]
[[Category: Dna binding protein]]
[[Category: Schumacher MA]]
[[Category: Plasmid segregation]]
[[Category: Tubr]]
[[Category: Winged helix-turn-helix]]
Retrieved from "https://proteopedia.org/3m9a"