2reo: Difference between revisions

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==Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP==
==Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP==
<StructureSection load='2reo' size='340' side='right' caption='[[2reo]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='2reo' size='340' side='right'caption='[[2reo]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2reo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2REO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2reo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2REO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2REO FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.651&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SULT1C3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2reo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2reo OCA], [http://pdbe.org/2reo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2reo RCSB], [http://www.ebi.ac.uk/pdbsum/2reo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2reo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2reo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2reo OCA], [https://pdbe.org/2reo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2reo RCSB], [https://www.ebi.ac.uk/pdbsum/2reo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2reo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ST1C3_HUMAN ST1C3_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.<ref>PMID:17936463</ref> <ref>PMID:17425406</ref>
[https://www.uniprot.org/uniprot/ST1C3_HUMAN ST1C3_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups (in vitro). May catalyze the sulfate conjugation of xenobiotic compounds and endogenous substrates.<ref>PMID:17936463</ref> <ref>PMID:17425406</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2reo_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/2reo_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bochkarev, A]]
[[Category: Arrowsmith CH]]
[[Category: Dong, A]]
[[Category: Bochkarev A]]
[[Category: Edwards, A M]]
[[Category: Dong A]]
[[Category: Loppnau, P]]
[[Category: Edwards AM]]
[[Category: Pan, P]]
[[Category: Loppnau P]]
[[Category: Plotnikov, A N]]
[[Category: Pan P]]
[[Category: Structural genomic]]
[[Category: Plotnikov AN]]
[[Category: Sundstrom, M]]
[[Category: Sundstrom M]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Pap]]
[[Category: Sgc]]
[[Category: Sulfate conjugation]]
[[Category: Sulfotransferase]]
[[Category: Transferase]]

Latest revision as of 11:55, 30 August 2023

Crystal structure of human sulfotransferase 1C3 (Sult1C3) in complex with PAP

2reo, resolution 2.65Å

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