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==CRYSTAL STRUCTURE OF THE CONSTITUTIVELY ACTIVE E113Q,N2C, D282C RHODOPSIN MUTANT WITH BOUND GALPHACT PEPTIDE.==
==CRYSTAL STRUCTURE OF THE CONSTITUTIVELY ACTIVE E113Q,D2C,D282C RHODOPSIN MUTANT WITH BOUND GALPHACT PEPTIDE.==
<StructureSection load='2x72' size='340' side='right' caption='[[2x72]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='2x72' size='340' side='right'caption='[[2x72]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2x72]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X72 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X72 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2x72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X72 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEF:DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE'>PEF</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ov0|1ov0]], [[1aqg|1aqg]], [[1n3m|1n3m]], [[2i37|2i37]], [[1bok|1bok]], [[2i36|2i36]], [[1lvz|1lvz]], [[1tag|1tag]], [[1edx|1edx]], [[2j4y|2j4y]], [[1fqk|1fqk]], [[1tnd|1tnd]], [[1vqx|1vqx]], [[1ln6|1ln6]], [[1jfp|1jfp]], [[1ov1|1ov1]], [[1f88|1f88]], [[1boj|1boj]], [[1eds|1eds]], [[1nzs|1nzs]], [[1u19|1u19]], [[1fqj|1fqj]], [[1tad|1tad]], [[1fdf|1fdf]], [[1edw|1edw]], [[1hzx|1hzx]], [[1l9h|1l9h]], [[2i35|2i35]], [[1gzm|1gzm]], [[1edv|1edv]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x72 OCA], [https://pdbe.org/2x72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x72 RCSB], [https://www.ebi.ac.uk/pdbsum/2x72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x72 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x72 OCA], [http://pdbe.org/2x72 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x72 RCSB], [http://www.ebi.ac.uk/pdbsum/2x72 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x72 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GNAT1_BOVIN GNAT1_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.  
[https://www.uniprot.org/uniprot/OPSD_BOVIN OPSD_BOVIN] Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).<ref>PMID:16908857</ref> <ref>PMID:17060607</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Rhodopsin|Rhodopsin]]
*[[Rhodopsin 3D structures|Rhodopsin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bovin]]
[[Category: Bos taurus]]
[[Category: Dantona, A]]
[[Category: Large Structures]]
[[Category: Edwards, P C]]
[[Category: Dantona A]]
[[Category: Fransen, M]]
[[Category: Edwards PC]]
[[Category: Oprian, D D]]
[[Category: Fransen M]]
[[Category: Schertler, G F.X]]
[[Category: Oprian DD]]
[[Category: Standfuss, J]]
[[Category: Schertler GFX]]
[[Category: Xie, G]]
[[Category: Standfuss J]]
[[Category: Chromophore]]
[[Category: Xie G]]
[[Category: G-protein coupled receptor]]
[[Category: Glycoprotein]]
[[Category: Lipoprotein]]
[[Category: Photoreceptor protein]]
[[Category: Retinal protein]]
[[Category: Sensory transduction]]
[[Category: Signaling protein]]
[[Category: Transmembrane]]
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