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==Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP complex (Rv2346c-Rv2347c)==
==Crystal structure of the Mycobacterium tuberculosis H37Rv EsxOP complex (Rv2346c-Rv2347c)==
<StructureSection load='3ogi' size='340' side='right' caption='[[3ogi]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='3ogi' size='340' side='right'caption='[[3ogi]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ogi]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OGI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OGI FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ogi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OGI FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.549&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT2411, MTCY98.15c, Rv2346c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884]), MT2412, MTCY98.16c, Rv2347c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ogi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ogi OCA], [http://pdbe.org/3ogi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ogi RCSB], [http://www.ebi.ac.uk/pdbsum/3ogi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ogi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ogi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ogi OCA], [https://pdbe.org/3ogi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ogi RCSB], [https://www.ebi.ac.uk/pdbsum/3ogi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ogi ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ESXO_MYCTU ESXO_MYCTU] Plays an important role in mycobacterial pathogenesis in the context of innate immunity. Aids host cell invasion and intracellular bacillary persistence. Increases host oxidative stress response, leading to genomic instability and decrease in macrophage viability. Also induces autophagy and modulates the immune function of macrophages.<ref>PMID:26786654</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/og/3ogi_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/og/3ogi_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ahn, C]]
[[Category: Large Structures]]
[[Category: Arbing, M A]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Cascio, D]]
[[Category: Ahn C]]
[[Category: Chan, S]]
[[Category: Arbing MA]]
[[Category: Eisenberg, D]]
[[Category: Cascio D]]
[[Category: Harris, L]]
[[Category: Chan S]]
[[Category: ISFI, Integrated Center for Structure and Function Innovation]]
[[Category: Eisenberg D]]
[[Category: Kuo, E]]
[[Category: Harris L]]
[[Category: Sawaya, M R]]
[[Category: Kuo E]]
[[Category: Structural genomic]]
[[Category: Sawaya MR]]
[[Category: Zhou, T T]]
[[Category: Zhou TT]]
[[Category: Integrated center for structure and function innovation]]
[[Category: Isfi]]
[[Category: PSI, Protein structure initiative]]
[[Category: Secreted]]
[[Category: Tbsgc]]
[[Category: Unknown function]]
[[Category: Wxg100]]
Retrieved from "https://proteopedia.org/3ogi"