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==Crystal structure of Bacillus subtilis toxin MazF in complex with cognate antitoxin MazE==
==Crystal structure of Bacillus subtilis toxin MazF in complex with cognate antitoxin MazE==
<StructureSection load='4me7' size='340' side='right' caption='[[4me7]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
<StructureSection load='4me7' size='340' side='right'caption='[[4me7]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4me7]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ME7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4me7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ME7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ME7 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.918&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mdx|4mdx]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BSU04660, mazF, ndoA, ydcE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU]), BSU04650, mazE, ndoAI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224308 BACSU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4me7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4me7 OCA], [https://pdbe.org/4me7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4me7 RCSB], [https://www.ebi.ac.uk/pdbsum/4me7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4me7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4me7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4me7 OCA], [http://pdbe.org/4me7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4me7 RCSB], [http://www.ebi.ac.uk/pdbsum/4me7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4me7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU]] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref> [[http://www.uniprot.org/uniprot/ENDAI_BACSU ENDAI_BACSU]] Antitoxin component of a toxin-antitoxin (TA) module. Antitoxin that directly inhibits activity of EndoA in vitro. Upon expression in E.coli counteracts inhibitory effect of mRNA interferase EndoA.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref> 
[https://www.uniprot.org/uniprot/ENDOA_BACSU ENDOA_BACSU] Toxic component of a toxin-antitoxin (TA) module. Has specificity for UACAU sequences, claving after the first U and yielding cleavage products with 3' phosphate and 5' hydroxyl groups. Overexpression is toxic for cell growth, probably by inhibiting protein synthesis through the cleavage of single-stranded RNA. The toxicity is reversed by the antitoxin EndoAI. Toxin activity cannot be inhibited by MazE from E.coli.<ref>PMID:15882409</ref> <ref>PMID:21763692</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacsu]]
[[Category: Bacillus subtilis subsp. subtilis str. 168]]
[[Category: Patel, D J]]
[[Category: Large Structures]]
[[Category: Simanshu, D K]]
[[Category: Patel DJ]]
[[Category: Antitoxin]]
[[Category: Simanshu DK]]
[[Category: Endoa]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Maze]]
[[Category: Maze-mazf]]
[[Category: Mazf]]
[[Category: Mrna clevage]]
[[Category: Mrna interferase]]
[[Category: Stress response]]
[[Category: Toxin-antitoxin system]]
[[Category: Ydce]]
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