1lud: Difference between revisions

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[[Image:1lud.gif|left|200px]]


{{Structure
==SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES==
|PDB= 1lud |SIZE=350|CAPTION= <scene name='initialview01'>1lud</scene>
<StructureSection load='1lud' size='340' side='right'caption='[[1lud]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene>
<table><tr><td colspan='2'>[[1lud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LUD FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TRR:2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM'>TRR</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lud OCA], [https://pdbe.org/1lud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lud RCSB], [https://www.ebi.ac.uk/pdbsum/1lud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lud ProSAT]</span></td></tr>
|RELATEDENTRY=[[1bzf|1BZF]], [[1ao8|1AO8]], [[3dfr|3DFR]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lud OCA], [http://www.ebi.ac.uk/pdbsum/1lud PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lud RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/DYR_LACCA DYR_LACCA] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/1lud_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lud ConSurf].
<div style="clear:both"></div>


'''SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES'''
==See Also==
 
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
1LUD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUD OCA].
[[Category: Lacticaseibacillus casei]]
 
[[Category: Large Structures]]
==Reference==
[[Category: Birdsall B]]
NMR-based solution structure of the complex of Lactobacillus casei dihydrofolate reductase with trimethoprim and NADPH., Polshakov VI, Smirnov EG, Birdsall B, Kelly G, Feeney J, J Biomol NMR. 2002 Sep;24(1):67-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12449420 12449420]
[[Category: Feeney J]]
[[Category: Dihydrofolate reductase]]
[[Category: Kelly G]]
[[Category: Lactobacillus casei]]
[[Category: Polshakov VI]]
[[Category: Single protein]]
[[Category: Smirnov EG]]
[[Category: Birdsall, B.]]
[[Category: Feeney, J.]]
[[Category: Kelly, G.]]
[[Category: Polshakov, V I.]]
[[Category: Smirnov, E G.]]
[[Category: dhfr]]
[[Category: inhibitor/enzyme complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:30 2008''

Latest revision as of 08:27, 10 April 2024

SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES

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