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==The E142L mutant of the amidase from Geobacillus pallidus==
==The E142L mutant of the amidase from Geobacillus pallidus==
<StructureSection load='4gyn' size='340' side='right' caption='[[4gyn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4gyn' size='340' side='right'caption='[[4gyn]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4gyn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsp Bacsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GYN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GYN FirstGlance]. <br>
<table><tr><td colspan='2'>[[4gyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_sp._(in:_Bacteria) Bacillus sp. (in: Bacteria)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GYN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gyl|4gyl]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">amiE, ami ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1409 BACSP])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gyn OCA], [https://pdbe.org/4gyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gyn RCSB], [https://www.ebi.ac.uk/pdbsum/4gyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gyn ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Amidase Amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.4 3.5.1.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gyn OCA], [http://pdbe.org/4gyn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gyn RCSB], [http://www.ebi.ac.uk/pdbsum/4gyn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gyn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AMIE_BACSP AMIE_BACSP]] Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia.<ref>PMID:10978771</ref>  Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates (By similarity).<ref>PMID:10978771</ref>
[https://www.uniprot.org/uniprot/AMIE_BACSP AMIE_BACSP] Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia.<ref>PMID:10978771</ref>  Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates (By similarity).<ref>PMID:10978771</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Amidase]]
[[Category: Large Structures]]
[[Category: Bacsp]]
[[Category: Cowan DA]]
[[Category: Cowan, D A]]
[[Category: Hunter R]]
[[Category: Hunter, R]]
[[Category: Kimani SW]]
[[Category: Kimani, S W]]
[[Category: Sewell BT]]
[[Category: Sewell, B T]]
[[Category: Varsani A]]
[[Category: Varsani, A]]
[[Category: Weber BW]]
[[Category: Weber, B W]]
[[Category: Amidase mechanism]]
[[Category: Catalytic tetrad]]
[[Category: Hydrolase]]
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