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==Apo structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit==
==Apo structure of 55 kDa N-terminal domain of E. coli DNA gyrase A subunit==
<StructureSection load='4ckk' size='340' side='right' caption='[[4ckk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='4ckk' size='340' side='right'caption='[[4ckk]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ckk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CKK FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ckk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CKK FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ckl|4ckl]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ckk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ckk OCA], [https://pdbe.org/4ckk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ckk RCSB], [https://www.ebi.ac.uk/pdbsum/4ckk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ckk ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ckk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ckk OCA], [http://pdbe.org/4ckk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ckk RCSB], [http://www.ebi.ac.uk/pdbsum/4ckk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ckk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GYRA_SHIFL GYRA_SHIFL]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).  
[https://www.uniprot.org/uniprot/A0A0H3JH39_ECO57 A0A0H3JH39_ECO57] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Gyrase|Gyrase]]
*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Edwards, M J]]
[[Category: Large Structures]]
[[Category: Hearnshaw, S J]]
[[Category: Edwards MJ]]
[[Category: Lawson, D M]]
[[Category: Hearnshaw SJ]]
[[Category: Maxwell, A]]
[[Category: Lawson DM]]
[[Category: Stevenson, C E.M]]
[[Category: Maxwell A]]
[[Category: Antibiotic target]]
[[Category: Stevenson CEM]]
[[Category: Dna gyrase]]
[[Category: Isomerase]]
[[Category: Topoisomerase]]
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