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==crystal structure of SHH1 SAWADEE domain in complex with H3K9me2 peptide==
==crystal structure of SHH1 SAWADEE domain in complex with H3K9me2 peptide==
<StructureSection load='4iut' size='340' side='right' caption='[[4iut]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4iut' size='340' side='right'caption='[[4iut]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4iut]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IUT FirstGlance]. <br>
<table><tr><td colspan='2'>[[4iut]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IUT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CVM:CYMAL-4'>CVM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CVM:CYMAL-4'>CVM</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iup|4iup]], [[4iuq|4iuq]], [[4iur|4iur]], [[4iuv|4iuv]], [[4iuu|4iuu]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iut OCA], [https://pdbe.org/4iut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iut RCSB], [https://www.ebi.ac.uk/pdbsum/4iut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iut ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">At1g15215, F9L1.16 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iut OCA], [http://pdbe.org/4iut PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iut RCSB], [http://www.ebi.ac.uk/pdbsum/4iut PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iut ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SHH1_ARATH SHH1_ARATH] Involved in RNA-directed DNA methylation (RdDM). Required for the silencing of some endogenous RdDM targets and accumulation of 24-nt siRNAs, but not for the production of Pol V-dependent transcripts. Functions in transcriptional silencing through both DNA methylation-dependent and -independent pathways. Required for both maintenance and de-novo DNA methylation. Plays a role in the recruitment of Pol IV to genomic regions associated with K9 methylated histone H3 that are targets for RdDM.<ref>PMID:21811420</ref> <ref>PMID:22064704</ref> <ref>PMID:23636332</ref> <ref>PMID:23637343</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Du, J]]
[[Category: Large Structures]]
[[Category: Patel, D J]]
[[Category: Du J]]
[[Category: Gene regulation]]
[[Category: Patel DJ]]
[[Category: H3k9me2]]
[[Category: Histone]]
[[Category: Mediate interaction]]
[[Category: Methylation]]
[[Category: Tandem tudor]]
[[Category: Zinc finger]]
Retrieved from "https://proteopedia.org/4iut"